Introduction: Surgical menopause is associated with decreased bone mineral density (BMD) and increased fractures. The prevalence of osteoporosis and osteopenia is varying through studies. In searching for specific bone protection strategy, factors contributing to bone loss or bone preservation in this population are needed to be explored.
Objectives: To determine the percentage of low bone mass among Thai surgical menopause women and to identify factors associated with low bone mass in Thai surgical menopausal women.
Methods: Medical records of surgical menopause women at King Chulalongkorn Memorial Hospital during 2002?2007 were reviewed. Anthropometric data, medical history and MHT data were collected. The BMD results after five years since surgery were analyzed. Chi-square test and Fisher-exact test for categorical variables, independent t-test for continuous variables and Mann-Whitney U test for nonparametric variables were used. Univariate and multivariate logistic regression model were performed to quantify the association.
Results: A total number of 146 women were included. The percentage of low bone mass was 65.75%. MHT usage rate was nearly 60%. The percentage of low bone mass women was higher in non-MHT users. Relative to patients, after all adjusted (Year since menopause, Age of menopause, BMI, Diabetes, Calcium, and Vitamin D), ever used hormone was associated with decreased odds of low bone mass (OR 0.31; 95% CI 0.13?0.74, p?=?0.008). Another associated factor was BMI. Each 1 unit increase in BMI was associated with decreased odds of low bone mass (OR 0.88; 95% CI 0.77?0.99, p?=?0.041).
Conclusion: More than half of surgical menopause were diagnosed as low bone mass at five years after surgery. MHT users group has lower percentage of low bone mass. In our study, only MHT uses and BMI were associated with lower rate of low bone mass.
|